周文科， 博士 副教授 硕士生导师
地址：武汉市东湖新技术开发区光谷一路206号
金沙威尼斯欢乐娱人城金沙威尼斯欢乐娱人城
邮编：430205
Email：2319552216@qq.com
电话：
教育背景
2001 – 2005 武汉大学生命科学学院，博士
1989 – 1992 华中农业大学植物保护系，硕士
1985 – 1989 华中农业大学园艺系，学士
工作履历
2014 至今 金沙威尼斯欢乐娱人城金沙威尼斯欢乐娱人城
2006 – 2013 美国匹兹堡大学医学院细胞生物学系，博士后
1992 – 2001 湖北省农业厅植物保护总站
学术兼职
研究领域
果蝇分子生物学。
以果蝇为模式生物研究人类重大疾病、
基因组编辑技术
奖励与荣誉
2001 湖北省“科技成果推广奖”二等奖
研究项目
国家自然科学基金面上项目，31970482，果蝇Dscam分子多样性及其在单个神经元水平上的表达谱研究，主持，2020.01 - 2023.12，主持
湖北省自然科学基金面上项目，2015CFB482，果蝇Crumbs蛋白分子调节Hippo肿瘤抑制信号通路，2015.01 - 2016.12，主持
学术成果
代表性论文：
1. Yuva-Aydemir, Y, Xu X, Aydemir O, Gascon E, Sayin S, Zhou W, Hong Y, Gao F. Down regulation of the Host Gene jigr1 by miR-92 Is Essential for Neuroblast Self-Renewal in Drosophila. PLoS Genetics. 2015; 11(5): e1005264~e1005264.
2. Zhou W, Hong Y. Drosophila Patj plays a supporting role in apical-basal polarity but is essential for viability. Development. 2012; 139(16):2891-6.
3. Zhou W, Huang J, Watson AM, Hong Y. W::neo: a novel dual-selection marker for high efficiency gene targeting in Drosophila. PLoS One. 2012; 7(2):e31997.
[Research hightlight by Nature Methods, see Nature Methods 2012 9(4): 326.]
4. Huang J, Zhou W, Dong W, Hong Y. Targeted engineering of the Drosophila genome. Fly (Austin). 2009; 3(4):274-7.
5. Huang J*, Zhou W*, Dong W, Watson AM, Hong Y. From the Cover: Directed, efficient, and versatile modifications of the Drosophila genome by genomic engineering. Proc Natl Acad Sci USA. 2009; 106(20):8284-9. (*:co-first author; cover title and issue highlight)
6. Huang J*, Zhou W*, Watson AM, Jan YN, Hong Y. Efficient ends-out gene targeting in Drosophila. Genetics. 2008;180(1):703-7. (*:co-first author; issue highlight)
7. Yao N, Yao LG, Kan YC, Zhou WK, Qi YP. Improvement of baculovirus expression system and purification of IL-6 protein expressed in insect cells. Sheng Wu Gong Cheng Xue Bao. 2006, 22(4):572-80. Chinese.
8. Zhou W*, Yao L*, Xu H, Yan F, Qi Y. The function of envelope protein P74 from Autographa californica multiple nucleopolyhedrovirus in primary infection to host. Virus Genes. 2005; 30(2):139-50. (*:co-first author)
9. Liu X*, Zhou W*, Zhang P, Xu Q, Hu C, Chen X, Yao L, Li L, Qi Y. Expression of SLAM (CDw150) on Sf9 cell surface mediates Measles Viral infection in the nonpermissive cells through SLAM/MVH interaction. Microbes and Infection. 2005; 7(11-12):1235-45. (*:co-first author)
10. Yao L, Zhou W, Xu H, Zheng Y, Qi Y. The Heliothis armigera single nucleocapsid nucleopolyhedrovirus envelope protein P74 is required for infection of the host midgut. Virus Res. 2004; 104(2):111-21.
